SS-31 (Elamipretide) is a cell-permeable, mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that selectively concentrates in the inner mitochondrial membrane. By binding to cardiolipin — a phospholipid critical for electron transport chain organisation — SS-31 stabilises mitochondrial cristae structure and optimises bioenergetic efficiency. It is a primary research compound for scientists investigating mitochondrial dysfunction and cellular energetics.
Mitochondrial Bioenergetics Research
SS-31’s unique ability to target cardiolipin at the inner mitochondrial membrane provides researchers with a precision tool for studying organelle-level bioenergetics. Key research areas include:
– Cardiolipin Interactions: Investigating the binding dynamics between SS-31 and cardiolipin, and how this stabilises cytochrome c association with the inner membrane.
– Electron Transport Chain Efficiency: Studying the peptide’s effects on Complex I-IV activity, electron leak, and overall oxidative phosphorylation efficiency in isolated mitochondria.
– ATP Production: Research into how cristae stabilisation affects F1Fo-ATP synthase function and cellular ATP yield in metabolically active cell lines.
Mechanisms and Oxidative Stress Research
SS-31’s mitochondrial localisation provides researchers with a unique tool for dissecting the relationship between organelle structure and function:
– ROS Attenuation: Investigating how cardiolipin stabilisation reduces mitochondrial superoxide production and prevents cardiolipin peroxidation in oxidative stress models.
– Membrane Potential Regulation: Studying the peptide’s effects on mitochondrial membrane potential (ΔΨm) maintenance and prevention of permeability transition pore opening.
– Mitochondrial Dynamics: Exploring how improved bioenergetics affect fission/fusion balance, mitophagy signalling, and mitochondrial network morphology in cellular models.
The SS-31 Pen: Precision for Laboratory Studies
Our SS-31 Pen delivery system is engineered to provide researchers with the ultimate tool for precise administration. Moving beyond traditional lyophilized vials, the pre-filled pen format ensures:
– Exact Dosing: Dial-in mechanisms allow for milligram-precise measurements, crucial for maintaining consistency in research protocols.
– Peptide Integrity: The airtight, light-resistant housing protects the peptide structure from environmental degradation and UV exposure.
– Streamlined Workflow: No manual syringe drawing or complex measuring is required, reducing the risk of contamination and human error.
– Stability: The pre-filled pen format is designed to maintain the peptide’s stability throughout use.
Disclaimer: This product is intended for laboratory and scientific research purposes only. SS-31 is not for human or animal consumption. It is not a drug, food, or cosmetic. Please ensure compliance with local regulations and laboratory safety protocols before purchase.
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