AOD-9604 is a synthetic peptide corresponding to the C-terminal region of human growth hormone (residues 176-191), with an additional tyrosine residue at the N-terminus. Originally developed as a metabolic research compound, it has become a widely used tool for investigating the lipolytic arm of growth hormone activity in isolation from the growth-promoting and glucoregulatory effects of the intact hormone.
Lipolysis and Adipocyte Research
AOD-9604 is of interest to laboratories studying how fat metabolism is regulated at the level of the adipocyte:
– Lipolytic Signalling: Investigating stimulation of triglyceride breakdown and free fatty acid release in isolated adipocyte cultures.
– Anti-Adipogenic Activity: Studying the peptide’s inhibitory effect on lipogenesis and the differentiation of preadipocytes into mature fat cells.
– Beta-3 Adrenergic Pathways: Research into the peptide’s relationship with beta-3 adrenergic receptor expression and downstream lipolytic cascades in adipose tissue models.
Dissociation from Growth Hormone Signalling
The principal research value of AOD-9604 lies in what it does not do. Unlike full-length hGH, the fragment has been characterised as acting without the systemic signalling that complicates whole-hormone studies:
– IGF-1 Independence: Investigating lipolytic effects in models where IGF-1 elevation is absent, allowing fat metabolism to be studied without confounding growth-factor signalling.
– Glucose Metabolism: Studying the fragment in insulin-sensitivity and glucose-uptake models where intact growth hormone would otherwise interfere.
– Receptor Selectivity: Research into how the 176-191 sequence exerts metabolic activity without conventional growth hormone receptor-mediated proliferation.
Structure and Characterisation
The 176-191 sequence represents the smallest region of human growth hormone shown in the literature to retain lipolytic activity, making AOD-9604 a useful model for structure-activity relationship work. Researchers use it to probe which domains of a large signalling protein are responsible for which downstream effects – a question of broad relevance to peptide fragment pharmacology.
The Research Pen: Precision for Laboratory Studies
Our pre-filled pen delivery system is engineered to give researchers a consistent, repeatable tool. Moving beyond traditional lyophilised vials, the pen format ensures:
– Exact Dosing: Dial-in mechanisms allow for precise, repeatable measurements, crucial for maintaining consistency across a research protocol.
– Peptide Integrity: The airtight, light-resistant housing protects the delicate peptide structure from environmental degradation and UV exposure.
– Streamlined Workflow: No reconstitution, manual syringe drawing or measuring is required, reducing the risk of contamination and human error.
– Stability: The pre-filled format is designed to maintain peptide stability throughout the life of the pen.
Each pen is quality controlled and COA verified, and ships from the UK.
Disclaimer: This product is intended for laboratory and scientific research purposes only. AOD-9604 is not for human or animal consumption. It is not a drug, food, or cosmetic. Please ensure compliance with local regulations and laboratory safety protocols before purchase.
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